منابع مشابه
Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma
Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation. Different scavenger molecules and detoxifying enzymes, such as glutathione (GSH) and glutathione peroxidase 4 (GPX4), have been shown to overwhelm o...
متن کاملTHE RELATIONSHIP BETWEEN ALUMINIUM TOXICITY AND IRON METABOLISM IN RATS
The relationship between aluminium toxicity and iron metabolism was studied. Male rats were exposed to aluminium by daily intraperitoneal injection of 40pmolelkg body weight. After 45 days, aluminium intoxified rats had a significant loweredserum ferritin (55%), iron (42%), TIBC (25%) and hemoglobin(31%). At thesame time the serum ceruloplasmin level was elevated by 60%. This result shows t...
متن کاملFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal small molecule erastin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemic...
متن کاملLeveraging the iron-starvation response to promote ferroptosis
An important micronutrient, iron is used by the cell either as an ion or upon assembly into heme or ironsulfur cluster (ISC) cofactors. Iron is generally not a free ion in the body, but is stored intracellularly by the protein ferritin and transported via association with transferrin. This iron sequestration is thought to occur because ironmediated lipid peroxidation via Fenton chemistry can re...
متن کاملHemochromatosis and Iron Metabolism
Hereditary hemochromatosis Hereditary hemochromatosis (HH) is characterized by abnormal iron absorption from the diet resulting in progressive iron overload, causing tissue damage of several organs, particularly the liver (1). Historically HH has been regarded as an extremely rare inborn error of metabolism causing "bronze diabetes", liver cirrhosis and hepatocellular carcinoma due to heavy iro...
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ژورنال
عنوان ژورنال: Russian Journal of Biotherapy
سال: 2017
ISSN: 1726-9784
DOI: 10.17650/1726-9784-2017-16-3-14-20